QTL Mapping II: Outbred Populations and Association Mapping
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CALL FOR PAPERS Updates on Mapping Quantitative Trait Loci QTL mapping in outbred populations: successes and challenges
Solberg Woods LC. QTL mapping in outbred populations: successes and challenges. Physiol Genomics 46: 81–90, 2014. First published December 10, 2013; doi:10.1152/physiolgenomics.00127.2013.—Quantitative trait locus (QTL) mapping in animal populations has been a successful strategy for identifying genomic regions that play a role in complex diseases and traits. When conducted in an F2 intercross ...
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There are two fundamentally different approaches for mapping QTLs in outbred populations. The first is to look at marker-trait associations in sets of relatives (such as sibs). The second, association mapping, uses collections of unrelated individuals, but requires very dense markers. Both rely on linkage disequilibrium, which is guaranteed in a set of relatives but not certain in a collection ...
متن کاملLecture 9 QTL and Association Mapping in Outbred Populations
There are two fundamentally different approaches for mapping QTLs in outbred populations. The first is to look at marker-trait associations in sets of relatives (such as sibs). The second, association mapping, uses collections of unrelated individuals, but requires very dense markers. Both rely on linkage disequilibrium, which is guaranteed in a set of relatives but not certain in a collection ...
متن کاملQTL mapping in outbred populations: successes and challenges.
Quantitative trait locus (QTL) mapping in animal populations has been a successful strategy for identifying genomic regions that play a role in complex diseases and traits. When conducted in an F2 intercross or backcross population, the resulting QTL is frequently large, often encompassing 30 Mb or more and containing hundreds of genes. To narrow the locus and identify candidate genes, addition...
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